Tricyclic antidepressants should be used with caution in patients with a history of alcoholism or who may use alcohol or other sedative medications because the depressant effects on the CNS can be potentiated.
Posted on August 8, 2010 by Penny
Epub ahead of print PMID: 19456855 PubMed kup amitriptyline Limited data suggest that tricyclic antidepressants used concomitantly with disulfiram can produce transient delirium. However, pharmacological similarities among the tricyclic antidepressant drugs require that each of the reactions be considered when amitriptyline is administered.